5-(trifluoromethyl)pyrid-2-ylhydrazine

Modify Date: 2024-01-08 11:39:04

5-(trifluoromethyl)pyrid-2-ylhydrazine Structure
5-(trifluoromethyl)pyrid-2-ylhydrazine structure
Common Name 5-(trifluoromethyl)pyrid-2-ylhydrazine
CAS Number 89570-85-4 Molecular Weight 177.12700
Density 1.442g/cm3 Boiling Point 280-285 °C(lit.)
Molecular Formula C6H6F3N3 Melting Point 102-106 °C(lit.)
MSDS N/A Flash Point 280-285°C

 Names

Name [5-(trifluoromethyl)pyridin-2-yl]hydrazine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.442g/cm3
Boiling Point 280-285 °C(lit.)
Melting Point 102-106 °C(lit.)
Molecular Formula C6H6F3N3
Molecular Weight 177.12700
Flash Point 280-285°C
Exact Mass 177.05100
PSA 50.94000
LogP 2.15930
Index of Refraction 1.528

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
2-Hydrazinyl-5-trifluoromethylpyridine
Product Name:
Synonyms:2-Hydrazinyl-5-(trifluoromethyl)pyridine

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H301:Toxic if swallowed
H319:Causes serious eye irritation
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

Section3. Composition/information on ingredients.
Ingredient name:2-Hydrazinyl-5-trifluoromethylpyridine
CAS number:89570-85-4

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
This product should be handled only by, or under the close supervision of, those properly qualified
Handling:
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C6H6F3N3
Molecular weight: 177.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
UN Number:UN2811 Class: 6.1 Packing group: III
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (2-Hydrazinyl-5-trifluoromethylpyridine)

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi
Risk Phrases R20/21/22
Safety Phrases S26-S36/37/39
HS Code 2933990090

 Synthetic Route

~90%

5-(trifluoromethyl)pyrid-2-ylhydrazine Structure

5-(trifluoromet...

CAS#:89570-85-4

Literature: AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O. Patent: WO2010/118063 A2, 2010 ; Location in patent: Page/Page column 113 ; WO 2010/118063 A2

~92%

5-(trifluoromethyl)pyrid-2-ylhydrazine Structure

5-(trifluoromet...

CAS#:89570-85-4

Literature: Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124

~87%

5-(trifluoromethyl)pyrid-2-ylhydrazine Structure

5-(trifluoromet...

CAS#:89570-85-4

Literature: Evans; Wah Wong; Wentrup Journal of the American Chemical Society, 1996 , vol. 118, # 17 p. 4009 - 4017

~%

5-(trifluoromethyl)pyrid-2-ylhydrazine Structure

5-(trifluoromet...

CAS#:89570-85-4

Literature: Heterocycles, , vol. 22, # 1 p. 117 - 124

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

MFCD00236724
2-hydrazinyl-5-trifluoromethylpyridine