PROTAC BRD9-binding moiety 5

Modify Date: 2023-01-21 12:27:18

PROTAC BRD9-binding moiety 5 structure	Common Name	PROTAC BRD9-binding moiety 5
	CAS Number	893633-37-9	Molecular Weight	346.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₈N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PROTAC BRD9-binding moiety 5

PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells[1].

Name	PROTAC BRD9-binding moiety 5

Description	PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD9:4.2 μM (IC50)
In Vitro	PROTAC BRD9-binding moiety 5 (compound 7) (0-250 μM; 48h) has antiproliferative activity against Jurkat, MDA-MB-231, A375 and HCT-116[1]. Cell Proliferation Assay[1] Cell Line: Jurkat, MDA-MB-231, A375 and HCT-116 Concentration: 0-250 μM Incubation Time: 48h Result: Exhibited antiproliferative activity against Jurkat, MDA-MB-231, A375 and HCT-116 with IC50s of 77 ± 7 μM, 125 ± 8 μM, 133 ± 5 μM and 145 ± 3 μM.
References	[1]. Pierri M, et al. Introducing structure-based three-dimensional pharmacophore models for accelerating the discovery of selective BRD9 binders. Bioorg Chem. 2022 Jan;118:105480.

Molecular Formula	C₁₉H₁₈N₆O
Molecular Weight	346.39