GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt structure
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Common Name | GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt | ||
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CAS Number | 87805-34-3 | Molecular Weight | 4169.48 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C186H275N51O59 | Melting Point | N/A | |
MSDS | USA | Flash Point | N/A |
Use of GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate saltGlucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor. |
Name | GLP-1 (1-37) amide |
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Synonym | More Synonyms |
Description | Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor. |
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Related Catalog | |
Target |
GLP-1 receptor[1] |
In Vitro | Glucagon-like peptide-1 (GLP-1) is produced by the posttranslational processing of proglucagon and acts as a regulator of various homeostatic events. GLP-1(1-37) is more stable than GLP-1(7-37), with 94.7% of the initial amount of peptide left after a 4h exposure to mouse serum. GLP-1(1-37) is confirmed to be a highly potent agonist of the GLP-1 receptor (GLP-1R) by measuring the expression of the luciferase reporter gene expression in transiently transfected human embryonic kidney (HEK293) cells[1]. |
In Vivo | GLP-1(1–37) decreased glycemic excursion in a dose-dependent. The administration of GLP-1(1–37) or GLP-1(7–37) markedly decrease blood glucose levels at 15 min and 30 min compared with the control group[1]. |
Cell Assay | HEK293 cells (5×104) are seeded in a 96-well plate and transiently cotransfected with the GLP-1R plasmid and the CRE-luciferase reporter plasmid. After a 48 h transfection, different concentrations of GLP-1(1–37) or GLP-1(7–37) are added, and the cells are incubated for 5 h. The cells are harvested for a luciferase assay using a luciferase assay[1]. |
Animal Admin | Mice[1] The normal KM mice are fasted for 16 h before the administration (i.p.) of GLP-1 and glucose. GLP-1(1-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is given in combination with glucose (4 g/kg). GLP-1(7-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is also administrated in combination with glucose (4 g/kg). The control group is treated with saline (NaCl, 9 g/l) and glucose (4 g/kg). The IPGTT is carried out at 0, 15, 30 and 60 min after glucose and protein administration, and the blood glucose levels are measured as described above[1]. |
References |
Molecular Formula | C186H275N51O59 |
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Molecular Weight | 4169.48 |
Storage condition | −20°C |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
GLP-1-related proteins attenuate the effects of mitochondrial membrane damage in pancreatic β cells.
Biochem. Biophys. Res. Commun. 447(1) , 133-8, (2014) Glucagon-like peptide (GLP)-1 analog based therapies are used not only for their insulinotropic effects, but also for their pleiotropic effects that improve pancreatic β cell function. Liraglutide is ... |
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Glucagon-like peptide-1 and blood pressure in young and healthy adults from the general population.
Hypertension 65(2) , 306-12, (2015) Hypertension and diabetes mellitus are highly correlated, but the underlying mechanisms are only partly understood. Therefore, the aim of our study was to investigate the relationships between plasma ... |
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The low level of glucagon-like peptide-1 (glp-1) is a risk factor of type 2 diabetes mellitus.
BMC Res. Notes 7 , 849, (2014) Glucagon like peptide-1 (GLP-1), an incretin hormone, regulates glucose metabolism by inducing insulin secretion and suppressing glucagon secretion. The aim of the study is to assess the levels of fas... |
Glucagon-like peptide 1 (1-37) |
Glucagon-like peptide 1 (1-37) (human, rat) |
Glucagon-like peptide 1 (1-37), human |