87805-34-3

87805-34-3 structure

Name: GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt
Chemical Name: GLP-1 (1-37) amide
CAS Number: 87805-34-3
Molecular Formula: C₁₈₆H₂₇₅N₅₁O₅₉
Molecular Weight: 4169.48
Catalog: API Hormone and endocrine-regulating drugs Pancreatic hormones and other blood sugar regulating drugs
Create Date: 2018-05-21 08:00:00
Modify Date: 2024-01-02 13:04:10
Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.

Name	GLP-1 (1-37) amide
Synonyms	Glucagon-like peptide 1 (1-37) Glucagon-like peptide 1 (1-37) (human, rat) Glucagon-like peptide 1 (1-37), human

Description	Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor Peptides Research Areas >> Metabolic Disease
Target	GLP-1 receptor[1]
In Vitro	Glucagon-like peptide-1 (GLP-1) is produced by the posttranslational processing of proglucagon and acts as a regulator of various homeostatic events. GLP-1(1-37) is more stable than GLP-1(7-37), with 94.7% of the initial amount of peptide left after a 4h exposure to mouse serum. GLP-1(1-37) is confirmed to be a highly potent agonist of the GLP-1 receptor (GLP-1R) by measuring the expression of the luciferase reporter gene expression in transiently transfected human embryonic kidney (HEK293) cells[1].
In Vivo	GLP-1(1–37) decreased glycemic excursion in a dose-dependent. The administration of GLP-1(1–37) or GLP-1(7–37) markedly decrease blood glucose levels at 15 min and 30 min compared with the control group[1].
Cell Assay	HEK293 cells (5×104) are seeded in a 96-well plate and transiently cotransfected with the GLP-1R plasmid and the CRE-luciferase reporter plasmid. After a 48 h transfection, different concentrations of GLP-1(1–37) or GLP-1(7–37) are added, and the cells are incubated for 5 h. The cells are harvested for a luciferase assay using a luciferase assay[1].
Animal Admin	Mice[1] The normal KM mice are fasted for 16 h before the administration (i.p.) of GLP-1 and glucose. GLP-1(1-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is given in combination with glucose (4 g/kg). GLP-1(7-37) (25 nmol/kg) with or without exendin(9-39) (250 nmol/kg) is also administrated in combination with glucose (4 g/kg). The control group is treated with saline (NaCl, 9 g/l) and glucose (4 g/kg). The IPGTT is carried out at 0, 15, 30 and 60 min after glucose and protein administration, and the blood glucose levels are measured as described above[1].
References	[1]. Zhao L, et al. Glucagon-like peptide-1(1-37) can enhance blood glucose homeostasis in mice. Regul Pept. 2012 Oct 10;178(1-3):1-5.

Molecular Formula	C₁₈₆H₂₇₅N₅₁O₅₉
Molecular Weight	4169.48
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

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