N-Arachidonyl maleimide
Modify Date: 2024-01-08 18:14:21
N-Arachidonyl maleimide structure
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Common Name | N-Arachidonyl maleimide | ||
|---|---|---|---|---|
| CAS Number | 876305-42-9 | Molecular Weight | 369.540 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 492.9±34.0 °C at 760 mmHg | |
| Molecular Formula | C24H35NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 185.2±18.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of N-Arachidonyl maleimideN-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM[1]. |
| Name | N-Arachidonyl maleimide,1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione |
|---|---|
| Synonym | More Synonyms |
| Description | N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM[1]. |
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| Related Catalog | |
| Target |
IC50: 140 nM (MAGL)[1] |
| In Vitro | N-Arachidonyl maleimide is a putative MAGL inhibitor, which can be used for modulation of the effects of 2-arachidonyl glycerol (2-AG). N-Arachidonyl maleimide increases endogenous levels of 2-AG in the brain. N-Arachidonyl maleimide prevents cerebellar membrane-mediated degradation of 2-AG at a relatively low concentration (IC50, 140 nM)[1]. |
| In Vivo | When combined with a 1 mg/kg dose of N-Arachidonyl maleimide, 2-AG (1, 3, and 10 mg/kg) produces significant and dose-dependent hypothermia, inhibition of locomotor activity, antinociception, and catalepsy[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 492.9±34.0 °C at 760 mmHg |
| Molecular Formula | C24H35NO2 |
| Molecular Weight | 369.540 |
| Flash Point | 185.2±18.0 °C |
| Exact Mass | 369.266785 |
| PSA | 37.38000 |
| LogP | 7.89 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.524 |
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Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling.
ChemBioChem. 11 , 218-27, (2010) 2-Arachidonoylglycerol plays a major role in endocannabinoid signaling, and is tightly regulated by the monoacylglycerol lipase (MAGL). Here we report the crystal structure of human MAGL. The protein ... |
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Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes.
Chem. Biol. 12 , 649-56, (2005) We have previously reported that the endocannabinoid, 2-arachidonoyl-glycerol (2-AG), is hydrolyzed in rat cerebellar membranes by monoglyceride lipase (MGL)-like enzymatic activity. The present study... |
| 1H-Pyrrole-2,5-dione, 1-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl]- |
| 1-[(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraen-1-yl]-1H-pyrrole-2,5-dione |
| 1-[(5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraen-1-yl]-1H-pyrrole-2,5-dione |