Dimethyl lithospermate B

Modify Date: 2025-09-11 19:13:16

Dimethyl lithospermate B Structure
Dimethyl lithospermate B structure
 Common Name Dimethyl lithospermate B
CAS Number 875313-64-7 Molecular Weight 746.667
Density 1.5±0.1 g/cm3 Boiling Point 968.3±65.0 °C at 760 mmHg
Molecular Formula C38H34O16 Melting Point N/A
MSDS N/A Flash Point 300.5±27.8 °C

 Use of Dimethyl lithospermate B


Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2].

 Names

Name (2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2R,3R)-2-(3,4-dihydroxyphenyl)-4-[(1E)-3-{[(2R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl]oxy}-3-oxo-1-propen-1-yl]-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylate
Synonym More Synonyms

 Dimethyl lithospermate B Biological Activity

Description Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2].
Related Catalog
Target

Na+ channel[1]

References

[1]. Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400.

[2]. Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 968.3±65.0 °C at 760 mmHg
Molecular Formula C38H34O16
Molecular Weight 746.667
Flash Point 300.5±27.8 °C
Exact Mass 746.184692
LogP 2.98
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.687
InChIKey DHYLGBJCEGEBGQ-QIBPRZLVSA-N
SMILES COC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)C=Cc1ccc(O)c2c1C(C(=O)OC(Cc1ccc(O)c(O)c1)C(=O)OC)C(c1ccc(O)c(O)c1)O2

 Synonyms

3-Benzofurancarboxylic acid, 2-(3,4-dihydroxyphenyl)-4-[(1E)-3-[(1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethoxy]-3-oxo-1-propen-1-yl]-2,3-dihydro-7-hydroxy-, (1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethyl ester, (2R,3R)-
(2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2R,3R)-2-(3,4-dihydroxyphenyl)-4-[(1E)-3-{[(2R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl]oxy}-3-oxo-1-propen-1-yl]-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylate
Dimethyl lithospermate B
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