122021-74-3
122021-74-3 structure
- Name: Magnesium Lithospermate B
- Chemical Name: magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
- CAS Number: 122021-74-3
- Molecular Formula: C36H28MgO16
- Molecular Weight: 740.903
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-07-11 00:59:36
- Modify Date: 2024-01-02 16:25:51
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Magnesium Lithospermate B is a derivative of caffeic acid tetramer and extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration[1][2][3].
| Name | magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate |
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| Synonyms |
Magnesium 2-({(2E)-3-[3-{[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl}-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]-2-propenoyl}oxy)-3-(3,4-dihydroxyphenyl)propanoate
Magnesium lithospermate B Monomethyl lithospermate B Magnesium aspartate hydrochloride trihydrate magnessium lithospermate B Magnesium lithospermate B,Magnesium Tanshinoate B Magnesate(1-),(L-aspartato(2-)-N,O(sup 1),O(sup 4))chloro-,hydrogen,(T-4),trihydrate Magnesium L-aspartate hydrochloride trihydrate 3-Benzofurancarboxylic acid, 4-[(1E)-3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, 3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethyl] ester, magnesium salt (1:1) (L-Aspartato(2-)-N,O(sup 1),O(sup 4))chloromagnesate(1-) hydrogen (T-4) trihydrate magnesium hydrogen chloride 2-aminobutanedioate(1:1:1:1) magnesium-L-aspartate hydrochloride |
| Description | Magnesium Lithospermate B is a derivative of caffeic acid tetramer and extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroinflammation and attenuates neurodegeneration[1][2][3]. |
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| Related Catalog | |
| In Vitro | Magnesium Lithospermate B (20-60 μg/ml; 24 h) decreases LDH activity in the cultured supernatant, increases SOD activity in cardiomyocytes, reduces intracellular ROS and MDA levels, and significantly suppresses cardiomyocytes apoptosis[2]. Magnesium Lithospermate B (1-100 μg/ml) enhances proliferation of neural stem cells (NSCs) in a dose-dependent manner[3]. Magnesium Lithospermate B (10 μg/ml) promotes the differentiation in vitro of NSCs towards neurons[3]. |
| In Vivo | Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats[1]. Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models[3]. Animal Model: Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats[1] Dosage: 2, 8 mg/kg Administration: P.o. once daily for 16 days Result: Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21. |
| References |
| Boiling Point | 1020.3ºC at 760mmHg |
|---|---|
| Molecular Formula | C36H28MgO16 |
| Molecular Weight | 740.903 |
| Flash Point | 322.1ºC |
| Exact Mass | 740.122803 |
| PSA | 283.70000 |
| LogP | 4.21090 |
| Vapour Pressure | 0mmHg at 25°C |