Acid-PEG8-S-S-PEG8-acid

Modify Date: 2024-01-08 09:41:34

Acid-PEG8-S-S-PEG8-acid Structure
Acid-PEG8-S-S-PEG8-acid structure
Common Name Acid-PEG8-S-S-PEG8-acid
CAS Number 873013-93-5 Molecular Weight 915.11200
Density N/A Boiling Point N/A
Molecular Formula C38H74O20S2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Acid-PEG8-S-S-PEG8-acid


Acid-PEG8-S-S-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyldisulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonym More Synonyms

 Acid-PEG8-S-S-PEG8-acid Biological Activity

Description Acid-PEG8-S-S-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C38H74O20S2
Molecular Weight 915.11200
Exact Mass 914.42100
PSA 272.88000
LogP 1.58280

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
HS Code 2930909090

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

PROPIONIC ACID OCTA(ETHYLENE GLYCOL)-DISULFIDE
PEG propionate disulfide
HOOC-PEG(8)-SS-PEG(8)-COOH
4,7,10,13,16,19,22,25,32,35,38,41,44,47,50,53-Hexadecaoxa-28,29-dithiahexapentacontanedioic acid
PEG acid disulfide (n=7)