Acid-PEG8-S-S-PEG8-acid

Names

[ Name ]:
Acid-PEG8-S-S-PEG8-acid

[Synonym ]:
PROPIONIC ACID OCTA(ETHYLENE GLYCOL)-DISULFIDE
PEG propionate disulfide
HOOC-PEG(8)-SS-PEG(8)-COOH
4,7,10,13,16,19,22,25,32,35,38,41,44,47,50,53-Hexadecaoxa-28,29-dithiahexapentacontanedioic acid
PEG acid disulfide (n=7)

Biological Activity

[Description]:

Acid-PEG8-S-S-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₇₄O₂₀S₂

[ Molecular Weight ]:
915.11200

[ Exact Mass ]:
914.42100

[ PSA ]:
272.88000

[ LogP ]:
1.58280

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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