Flovagatran
Modify Date: 2024-01-30 21:13:51
Flovagatran structure
|
Common Name | Flovagatran | ||
|---|---|---|---|---|
| CAS Number | 871576-03-3 | Molecular Weight | 525.40200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H36BN3O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FlovagatranFlovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis[1]. |
| Name | [(1R)-4-methoxy-1-[[(2S)-1-[(2R)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs[1]. Animal Model: Chicks[1] Dosage: 1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes. 2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes. 5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes. Administration: Bolus plus infusion Result: Elevated PD markers, and produced minimal post-operative blood loss. |
| Molecular Formula | C27H36BN3O7 |
|---|---|
| Molecular Weight | 525.40200 |
| Exact Mass | 525.26500 |
| PSA | 144.41000 |
| LogP | 2.84100 |
| Cbz-Phe-Pro-BoroMpg-OH |
| TGN 255 |