871576-03-3

871576-03-3 structure

Name: Flovagatran
Chemical Name: [(1R)-4-methoxy-1-[[(2S)-1-[(2R)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid
CAS Number: 871576-03-3
Molecular Formula: C₂₇H₃₆BN₃O₇
Molecular Weight: 525.40200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
Create Date: 2016-05-03 09:05:04
Modify Date: 2024-01-30 21:13:51
Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis[1].

Name	[(1R)-4-methoxy-1-[[(2S)-1-[(2R)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]pyrrolidine-2-carbonyl]amino]butyl]boronic acid
Synonyms	Cbz-Phe-Pro-BoroMpg-OH TGN 255

Description	Flovagatran (TGN 255) is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran can be used in the research of arterial and venous thrombosis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
In Vivo	Flovagatran (2.5-mg/kg bolus plus 10 mg/kg/h for 90 minutes) produces anticoagulation effects in dogs[1]. Animal Model: Chicks[1] Dosage: 1.0-mg/kg bolus and then 4 mg/kg/h for 90 minutes. 2.5-mg/kg bolus and then 10 mg/kg/h for 90 minutes. 5.0-mg/kg bolus and then 20 mg/kg/h for 90 minutes. Administration: Bolus plus infusion Result: Elevated PD markers, and produced minimal post-operative blood loss.