Tozadenant structure
|
Common Name | Tozadenant | ||
---|---|---|---|---|
CAS Number | 870070-55-6 | Molecular Weight | 406.499 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C19H26N4O4S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of TozadenantTozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A. |
Name | 4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-4-methylpiperidine-1-carboxamide |
---|---|
Synonym | More Synonyms |
Description | Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A. |
---|---|
Related Catalog | |
Target |
Ki: 6 nM (Rhesus A2A), 11.5 nM (Human A2A) |
In Vivo | 18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant[1]. |
References |
Density | 1.4±0.1 g/cm3 |
---|---|
Molecular Formula | C19H26N4O4S |
Molecular Weight | 406.499 |
Exact Mass | 406.167480 |
PSA | 118.89000 |
LogP | 0.43 |
Index of Refraction | 1.662 |
HS Code | 2934999090 |
---|
~78% Tozadenant CAS#:870070-55-6 |
Literature: Flohr, Alexander; Moreau, Jean-Luc; Poli, Sonia Maria; Riemer, Claus; Steward, Lucinda Patent: US2005/261289 A1, 2005 ; Location in patent: Page/Page column 7 ; US 20050261289 A1 |
Precursor 2 | |
---|---|
DownStream 0 |
HS Code | 2934999090 |
---|---|
Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
4-hydroxy-n-(4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl)-4-methyl-1-piperidinecarboxamide |
4-hydroxy-4-methyl-piperidine-1-carboxylic acid(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide |
Tozadenant |
SYN-115 |
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-1,3-benzothiazol-2-yl]-4-methyl-1-piperidinecarboxamide |
4-Hydroxy-N-(4-methoxy-7-morpholinobenzo(d)thiazol-2-yl)-4-methylpiperidine-1-carboxamide |
Tozadenant (USAN) |
1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl- |
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide |