CAY10500
Modify Date: 2024-01-04 20:51:07
CAY10500 structure
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Common Name | CAY10500 | ||
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| CAS Number | 869998-49-2 | Molecular Weight | 547.611 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 589.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C32H32F3N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 310.2±30.1 °C | |
Use of CAY10500SPD304 is a selective inhibitor of tumor necrosis factor α (TNFα) and promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor, with an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2]. SPD304 cannot be used in vivo due to its high toxicity[3]. |
| Name | 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one |
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| Synonym | More Synonyms |
| Description | SPD304 is a selective inhibitor of tumor necrosis factor α (TNFα) and promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor, with an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2]. SPD304 cannot be used in vivo due to its high toxicity[3]. |
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| Related Catalog | |
| Target |
IC50: 22 µM (TNFα)[1]. |
| In Vitro | SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation[4]. |
| References |
[1]. Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 589.2±50.0 °C at 760 mmHg |
| Molecular Formula | C32H32F3N3O2 |
| Molecular Weight | 547.611 |
| Flash Point | 310.2±30.1 °C |
| Exact Mass | 547.244690 |
| PSA | 41.62000 |
| LogP | 8.23 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.583 |
| 4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]- |
| 6,7-Dimethyl-3-[(methyl{2-[methyl({1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl}methyl)amino]ethyl}amino)methyl]-4H-chromen-4-one |