A-770041

Modify Date: 2024-01-16 17:47:09

A-770041 structure	Common Name	A-770041
	CAS Number	869748-10-7	Molecular Weight	621.73200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₉N₉O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of A-770041

A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.IC50 value: 147 nMTarget: Lck

Name	N-[4-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide
Synonym	More Synonyms

Description	A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.IC50 value: 147 nMTarget: Lck
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Inflammation/Immunology
References	[1]. Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41. [2]. Andrew Burchat, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection Bioorganic & Medicinal Chemistry Letters Volume 16, Issue 1, 1 January 2006, Pages 118-122

Description

Related Catalog

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

Research Areas >> Inflammation/Immunology

References

[1]. Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41.

[2]. Andrew Burchat, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection Bioorganic & Medicinal Chemistry Letters Volume 16, Issue 1, 1 January 2006, Pages 118-122

Molecular Formula	C₃₄H₃₉N₉O₃
Molecular Weight	621.73200
Exact Mass	621.31800
PSA	139.92000
LogP	5.31690

2c0o

Kinome_3267

CS-0057

A-770041

DC Chemicals Limited
China
Product Name: A-770041
Price: $Inquiry/25mg $Inquiry/50mg $Inquiry/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $438/10mM*1mLinDMSO

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A-770041

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