Rhodiosin

Modify Date: 2024-01-04 20:37:46

Rhodiosin structure	Common Name	Rhodiosin
	CAS Number	86831-54-1	Molecular Weight	610.518
	Density	1.8±0.1 g/cm3	Boiling Point	994.3±65.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₃₀O₁₆	Melting Point	N/A
	MSDS	N/A	Flash Point	329.1±27.8 °C

Use of Rhodiosin

Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM[1]. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL[2]. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC50 of 27.77 μM[3].

Name	herbacetin 7-O-(3''-O-β-D-glucopyranosyl-α-L-rhamnopyranoside)
Synonym	More Synonyms

Description	Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM[1]. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL[2]. Rhodiosin exhibits potent DPPH free radical scavenging activities, with an IC50 of 27.77 μM[3].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 0.420 μM (cytochrome P450 2D6)[1]；57.50-2.43 μg/mL (AChE)[2]；27.77 μM (DPPH free radical scavenging)[3]
References	[1]. Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in Rhodiola rosea. Pharmazie. 2013 Dec;68(12):974-6. [2]. Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532. [3]. Choe KI, et al. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of Rhodiola sachalinensis A. BOR. Molecules. 2012 Sep 27;17(10):11484-94.

Density	1.8±0.1 g/cm3
Boiling Point	994.3±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₀O₁₆
Molecular Weight	610.518
Flash Point	329.1±27.8 °C
Exact Mass	610.153381
PSA	269.43000
LogP	-2.25
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.765