DM-NOFD
Modify Date: 2025-09-10 03:15:10
DM-NOFD structure
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Common Name | DM-NOFD | ||
|---|---|---|---|---|
| CAS Number | 865488-53-5 | Molecular Weight | 265.262 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C13H15NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DM-NOFDThe dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation. |
| Name | DM-NOFD |
|---|---|
| Synonym | More Synonyms |
| Description | The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation. |
|---|---|
| References | References 1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73. 2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. View Related Products by Target HIF/HIF Prolyl-hydroxylase |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C13H15NO5 |
| Molecular Weight | 265.262 |
| Exact Mass | 265.095032 |
| LogP | 1.61 |
| Index of Refraction | 1.518 |
| N-Oxalyl-D-phenylalanine dimethyl ester |
| N-(2-Methoxy-2-oxoacetyl)-D-phenylalanine methyl ester |
| Dimethyl N-oxalyl-D-phenylalanine |
| DM-NOFD |
| D-Phenylalanine, N-(2-methoxy-1,2-dioxoethyl)-, methyl ester |
| Methyl N-[methoxy(oxo)acetyl]-D-phenylalaninate |