865488-53-5

865488-53-5 structure

Name: DM-NOFD
Chemical Name: DM-NOFD
CAS Number: 865488-53-5
Molecular Formula: C₁₃H₁₅NO₅
Molecular Weight: 265.262
Create Date: 2020-01-11 20:35:51
Modify Date: 2024-02-08 09:23:16
The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.

Name	DM-NOFD
Synonyms	N-Oxalyl-D-phenylalanine dimethyl ester N-(2-Methoxy-2-oxoacetyl)-D-phenylalanine methyl ester Dimethyl N-oxalyl-D-phenylalanine DM-NOFD D-Phenylalanine, N-(2-methoxy-1,2-dioxoethyl)-, methyl ester Methyl N-[methoxy(oxo)acetyl]-D-phenylalaninate

Description	The dimethyl ester of N-oxalyl-d-phenylalanine (NOFD), a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM); also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM); more efficiently reduces HIF1α CAD hydroxylation.
References	References 1. Chan MC, et al. J Biol Chem. 2016 Sep 23;291(39):20661-73. 2. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. View Related Products by Target HIF/HIF Prolyl-hydroxylase