Auxinole

Modify Date: 2025-08-27 09:25:55

Auxinole Structure
Auxinole structure
Common Name Auxinole
CAS Number 86445-22-9 Molecular Weight 321.37
Density N/A Boiling Point N/A
Molecular Formula C20H19NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Auxinole


Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression.

 Names

Name Auxinole

 Auxinole Biological Activity

Description Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression.
Related Catalog
Target

TIR1/AFB receptor[1]

In Vitro Auxinole is a potent auxin antagonist of TIR1/AFB receptors, and binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and then inhibits auxin-responsive gene expression. In addition, Auxinole competitively inhibits various auxin responses in planta[1]. Auxinole causes reduction in IAA-triggered depolarization in root hair cells. Auxinole (20 µM) also represses the transient increase in [Ca2+]cyt completely, and blocks Ca2+ response[2].
References

[1]. Hayashi K, et al. Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex. ACS Chem Biol. 2012 Mar 16;7(3):590-8.

[2]. Dindas J, et al. AUX1-mediated root hair auxin influx governs SCFTIR1/AFB-type Ca2+ signaling. Nat Commun. 2018 Mar 21;9(1):1174.

 Chemical & Physical Properties

Molecular Formula C20H19NO3
Molecular Weight 321.37
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