12R-LOX-IN-1

12R-LOX-IN-1 Structure
12R-LOX-IN-1 structure
Common Name 12R-LOX-IN-1
CAS Number 857758-13-5 Molecular Weight 237.25
Density N/A Boiling Point N/A
Molecular Formula C15H11NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 12R-LOX-IN-1


12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].

 Names

Name 12R-LOX-IN-1

 12R-LOX-IN-1 Biological Activity

Description 12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].
Related Catalog
References

[1]. Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.  

 Chemical & Physical Properties

Molecular Formula C15H11NO2
Molecular Weight 237.25
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