12R-LOX-IN-1

Names

[ CAS No. ]:
857758-13-5

[ Name ]:
12R-LOX-IN-1

Biological Activity

[Description]:

12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC50: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Bhuktar H, et al. Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX. Bioorg Chem. 2023 Sep;138:106606.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H11NO2

[ Molecular Weight ]:
237.25

Related Compounds

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