Sanggenon G
Modify Date: 2024-04-09 15:47:36
Sanggenon G structure
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Common Name | Sanggenon G | ||
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| CAS Number | 85698-31-3 | Molecular Weight | 694.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H38O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Sanggenon GSanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation[1]. |
| Name | (2S)-6-[(1S,5R,6S)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-(4-methylpent-3-enyl)cyclohex-2-en-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one |
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| Description | Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP). Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation[1]. |
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| Related Catalog | |
| Target |
Caspase-3 Caspase-8 Caspase-9 |
| In Vitro | Sanggenon G (14.4 μM, 24 h) 增强 caspase-8、-3 和 -9 的切割，从 XIAP 中置换 caspase-9 并使 Molt3/XIAP 细胞对 Etoposide (HY-13629) 诱导的细胞凋亡敏感[1]。 Sanggenon G 不仅使过表达 XIAP 的白血病细胞系 Molt3/XIAP 对依托泊苷 (HY-13629) 治疗敏感，而且使内源性表达高水平 XIAP 的不同神经母细胞瘤细胞系敏感[1]。 |
| References |
| Molecular Formula | C40H38O11 |
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| Molecular Weight | 694.72 |