Safflor yellow A

Modify Date: 2024-01-06 16:58:44

Safflor yellow A structure	Common Name	Safflor yellow A
	CAS Number	85532-77-0	Molecular Weight	610.51700
	Density	1.81g/cm3	Boiling Point	942.3ºC at 760 mmHg
	Molecular Formula	C₂₇H₃₀O₁₅	Melting Point	N/A
	MSDS	N/A	Flash Point	313ºC

Use of Safflor yellow A

Safflor yellow A, a flavonoid extracted from Carthamus tinctorius L, is a water-soluble monomer of safflor yellow. Safflor yellow A protects rat cardiomyocytes against anoxia/reoxygenation (A/R) injury via inhibiting cellular oxidative stress and apoptosis[1].

Name	safflor yellow (A)

Description	Safflor yellow A, a flavonoid extracted from Carthamus tinctorius L, is a water-soluble monomer of safflor yellow. Safflor yellow A protects rat cardiomyocytes against anoxia/reoxygenation (A/R) injury via inhibiting cellular oxidative stress and apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology
In Vivo	Pretreatment with Safflor yellow A (40, 60 and 80 nM) concentration-dependently blockes the A/R-induced changes in the cardiomyocytes in 1- to 3-d-old Sprague-Dawley rats [1].
References	[1]. Duan JL, et al. Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro. Acta Pharmacol Sin. 2013 Apr;34(4):487-95.

Density	1.81g/cm3
Boiling Point	942.3ºC at 760 mmHg
Molecular Formula	C₂₇H₃₀O₁₅
Molecular Weight	610.51700
Flash Point	313ºC
Exact Mass	610.15300
PSA	273.36000
Index of Refraction	1.764

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0333750

CHEMICAL NAME :: 9H-Pyrano(3,2-b)benzofuran-9-one, 2,3,4,4a,6,9b-hexahydro-6-beta-D-glucopyranosyl-2- (hydroxymethyl)-8-(3-(4-hydroxyphenyl)-1-oxo-2-propen yl)-3,4,6,7-tetrahydr oxy-

CAS REGISTRY NUMBER :: 85532-77-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H30-O15

MOLECULAR WEIGHT :: 594.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5530 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5490 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SAFFLOR YELLOW A
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Purity: 98.0%
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Safflor yellow A

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA