Safflor yellow A

Names

[ Name ]:
Safflor yellow A

Biological Activity

[Description]:

Safflor yellow A, a flavonoid extracted from Carthamus tinctorius L, is a water-soluble monomer of safflor yellow. Safflor yellow A protects rat cardiomyocytes against anoxia/reoxygenation (A/R) injury via inhibiting cellular oxidative stress and apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cardiovascular Disease

Research Areas >> Inflammation/Immunology

[In Vivo]

Pretreatment with Safflor yellow A (40, 60 and 80 nM) concentration-dependently blockes the A/R-induced changes in the cardiomyocytes in 1- to 3-d-old Sprague-Dawley rats [1].

[References]

[1]. Duan JL, et al. Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro. Acta Pharmacol Sin. 2013 Apr;34(4):487-95.

Chemical & Physical Properties

[ Density]:
1.81g/cm3

[ Boiling Point ]:
942.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₇H₃₀O₁₅

[ Molecular Weight ]:
610.51700

[ Flash Point ]:
313ºC

[ Exact Mass ]:
610.15300

[ PSA ]:
273.36000

[ Index of Refraction ]:
1.764

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0333750

CHEMICAL NAME :: 9H-Pyrano(3,2-b)benzofuran-9-one, 2,3,4,4a,6,9b-hexahydro-6-beta-D-glucopyranosyl-2- (hydroxymethyl)-8-(3-(4-hydroxyphenyl)-1-oxo-2-propen yl)-3,4,6,7-tetrahydr oxy-

CAS REGISTRY NUMBER :: 85532-77-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H30-O15

MOLECULAR WEIGHT :: 594.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5530 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5490 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984

Related Compounds

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