SAMT-247
Modify Date: 2025-08-26 10:34:57
SAMT-247 structure
|
Common Name | SAMT-247 | ||
|---|---|---|---|---|
| CAS Number | 850715-59-2 | Molecular Weight | 266.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H14N2O3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SAMT-247SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2]. |
| Name | Ethanethioic acid, S-[2-[[(3-amino-3-oxopropyl)amino]carbonyl]phenyl] ester |
|---|
| Description | SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
HIV-1IIIB:0.6 μM (EC50) |
| In Vitro | SAMT-247 通过共价修饰 Gag 多聚蛋白[2]。 SAMT-247 在被 HIV-1IIIB 感染的 CEM-SS 细胞中显示出 EC50 为 0.6 μM 的抗病毒活性。SAMT-247 显示出较低的细胞毒性(TC50 > 100 μM)[2]。 |
| In Vivo | 含有 1% SAMT-247 的凝胶配方保护了六只恒河猴中的五只免受 CCR5(R5)-趋向性 SHIV 阴道感染[3]。 |
| References |
| Molecular Formula | C12H14N2O3S |
|---|---|
| Molecular Weight | 266.32 |
| Exact Mass | 266.07300 |
| PSA | 114.56000 |
| LogP | 2.02160 |
| InChIKey | UNACIIIRYSLSOD-UHFFFAOYSA-N |
| SMILES | CC(=O)Sc1ccccc1C(=O)NCCC(N)=O |
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Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.
AIDS 25(15) , 1833-41, (2011) Development of an effective vaccine or topical compound to prevent HIV transmission remains a major goal for control of the AIDS pandemic. Using a nonhuman primate model of heterosexual HIV-1 transmis... |