1,2,3,6-Tetrahydrophthalic anhydride

Modify Date: 2025-08-24 16:36:15

1,2,3,6-Tetrahydrophthalic anhydride structure	Common Name	1,2,3,6-Tetrahydrophthalic anhydride
	CAS Number	85-43-8	Molecular Weight	152.147
	Density	1.3±0.1 g/cm3	Boiling Point	305.6±42.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₃	Melting Point	101-102°C
	MSDS	N/A	Flash Point	148.3±25.1 °C

Name	Cis-1,2,3,6-Tetrahydrophthalic Anhydride
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	305.6±42.0 °C at 760 mmHg
Melting Point	101-102°C
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	148.3±25.1 °C
Exact Mass	152.047348
PSA	43.37000
LogP	0.10
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.529

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GW5775000

CHEMICAL NAME :: 4-Cyclohexene-1,2-dicarboxylic anhydride

CAS REGISTRY NUMBER :: 85-43-8

BEILSTEIN REFERENCE NO. :: 0082340

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: T56 BVOV GUTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,322,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,322,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >294 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >294 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,780,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(12),37,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2931 No. of Facilities: 39 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 1584 (estimated) No. of Female Employees: 547 (estimated)

Risk Phrases	R41
Safety Phrases	S26-S36/37/39
RIDADR	2698
Packaging Group	III
Hazard Class	8

o-xylene

CAS#:95-47-6

4-Cyclohexene-1...

CAS#:7500-55-2

~0%

N/A

CAS#:1352221-13-6

1,2,3,6-Tetrahy...

CAS#:85-43-8

Literature: UBE INDUESTRIES, LTD.; Yamamoto, Yasushi; Yatabe, Hikaru Patent: US2013/41174 A1, 2013 ; Location in patent: Paragraph 0051; 0072 ;

Maleic anhydride

CAS#:108-31-6

butadiene

CAS#:106-99-0

~80%

1,2,3,6-Tetrahy...

CAS#:85-43-8

Literature: Baker, Raymond; Billington, David C.; Ekanayake, Neelakanthie Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 7 p. 1387 - 1393

Maleic anhydride

CAS#:108-31-6

1,2-butadiene

CAS#:590-19-2

1,2,3,6-Tetrahy...

CAS#:85-43-8

Literature: Organic Syntheses, , vol. 30, p. 93

Precursor 5
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CAS#:590-19-2 1,2-butadiene
DownStream 10
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