2-Methyl-5-HT hydrochloride

Modify Date: 2025-09-15 08:10:10

2-Methyl-5-HT hydrochloride Structure
2-Methyl-5-HT hydrochloride structure
Common Name 2-Methyl-5-HT hydrochloride
CAS Number 845861-49-6 Molecular Weight 226.70300
Density N/A Boiling Point N/A
Molecular Formula C11H15ClN2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2-Methyl-5-HT hydrochloride


2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].

 Names

Name 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol,hydrochloride
Synonym More Synonyms

 2-Methyl-5-HT hydrochloride Biological Activity

Description 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects[1].
Target

5-HT3 Receptor

In Vivo 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) (i.p.; 3 mg/kg; 45 minutes) significantly decreases time of immobility as compared to controls thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.
References

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

 Chemical & Physical Properties

Molecular Formula C11H15ClN2O
Molecular Weight 226.70300
Exact Mass 226.08700
PSA 62.04000
LogP 3.18540
InChIKey ZNVRHQPXSBWLQP-UHFFFAOYSA-N
SMILES Cc1[nH]c2ccc(O)cc2c1CCN.Cl

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-Methylserotonin.HCl
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