JNJ-26070109
Modify Date: 2025-08-25 19:08:09
JNJ-26070109 structure
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Common Name | JNJ-26070109 | ||
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| CAS Number | 844645-08-5 | Molecular Weight | 547.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H17BrF2N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ-26070109A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats. |
| Name | JNJ-26070109 |
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| Description | A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats. |
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| References | References 1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36. 2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93. View Related Products by Target Cholecystokinin Receptor |
| Molecular Formula | C23H17BrF2N4O3S |
|---|---|
| Molecular Weight | 547.37 |
| InChIKey | TZKCPFFVWLRNRZ-CYBMUJFWSA-N |
| SMILES | CC(NC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)c1ccc(F)cc1F |