4,4'-Methylene di-o-toluidine

Modify Date: 2025-08-20 13:27:38

4,4'-Methylene di-o-toluidine structure	Common Name	4,4'-Methylene di-o-toluidine
	CAS Number	838-88-0	Molecular Weight	226.317
	Density	1.1±0.1 g/cm3	Boiling Point	406.6±40.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₈N₂	Melting Point	155-157 °C
	MSDS	USA	Flash Point	238.9±26.8 °C
	Symbol	GHS07, GHS08, GHS09	Signal Word	Danger

Name	4,4'-Diamino-3,3'-Dimethyldiphenylmethane
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	406.6±40.0 °C at 760 mmHg
Melting Point	155-157 °C
Molecular Formula	C₁₅H₁₈N₂
Molecular Weight	226.317
Flash Point	238.9±26.8 °C
Exact Mass	226.147003
PSA	52.04000
LogP	2.56
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.634
InChIKey	WECDUOXQLAIPQW-UHFFFAOYSA-N
SMILES	Cc1cc(Cc2ccc(N)c(C)c2)ccc1N

4,4'-Methylene di-o-toluidine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY5300000

CHEMICAL NAME :: Aniline, 4,4'-methylenebis(2-methyl-

CAS REGISTRY NUMBER :: 838-88-0

BEILSTEIN REFERENCE NO. :: 0398069

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C15-H18-N2

MOLECULAR WEIGHT :: 226.35

WISWESSER LINE NOTATION :: ZR B1 D1R DZ C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4656 mg/kg/55W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4900 mg/kg/4Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4820 mg/kg/69W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6500 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 49,185,1982 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,248,1987 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,248,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,248,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993

Symbol	GHS07, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H302-H317-H350-H410
Precautionary Statements	P201-P273-P280-P308 + P313-P501
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;N: Dangerous for the environment;
Risk Phrases	R45;R22;R43;R50/53
Safety Phrases	S53-S45-S60-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	BY5300000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2921590090

Precursor 7
CAS#:50-00-0 Formaldehyde CAS#:95-53-4 o-Toluidine CAS#:88919-92-0 N-(methoxymethy... CAS#:636-21-5 o-Toluidine HCl
CAS#:91-78-1 1,3,5-Triazine,... CAS#:108-44-1 3-Toluidine CAS#:72621-64-8 2-methyl-4-[(2-...
DownStream 7
CAS#:139-25-3 1,1'-Methyleneb... CAS#:6864-37-5 bis(4-amino-3-m... CAS#:1201895-82-0 (4-amino-3-meth... CAS#:2467-25-6 4,4'-Methyleneb...
CAS#:71655-97-5 N-[2-methyl-4-[... CAS#:67277-73-0 1-methyl-5-[(5-... CAS#:64497-21-8 4-[(4-aminophen...

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Some native epithelia, for example, retinal pigment epithelium (RPE) and kidney proximal tubule (KPT), constitutively lack the basolateral sorting adaptor AP-1B; this results in many basolateral plasm...

The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man.

Environ. Res. 27(2) , 241-54, (1982)

Aromatic amines of major industrial importance: use and occurrence.

IARC Sci. Publ. (40) , 51-74, (1981)

4,4'-Diamino-3,3'-dimethyldiphenylmethane

4,4'-Methylene di-o-toluidine

Benzenamine, 4,4'-methylenebis[2-methyl-

MFCD00126963

4,4'-Methylen-bis(2-methyl aniline)

EINECS 212-658-8

4,4'-Methylenebis(2-methylaniline)

4,4'-Methylene-di(o-toluidine)

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline

4,4'-methanediylbis(2-methylaniline)

Methane, bis[4-amino-3-methylphenyl]-

4,4'-Methylene-bis(2-methylaniline)

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4,4'-Methylene di-o-toluidine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4,4'-Methylene di-o-toluidine
Price: ￥378.0/100mg ￥188.0/5g ￥538.0/25g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,4'-Diamino-3,3'-dimethyldiphenylmethane
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4,4'-DIAMINO-3,3'-DIMETHYLDIPHENYLMETHANE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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4,4'-Methylene di-o-toluidine

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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