Fenmetozole Tosylate
Modify Date: 2025-09-10 19:30:01
Fenmetozole Tosylate structure
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Common Name | Fenmetozole Tosylate | ||
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| CAS Number | 83474-08-2 | Molecular Weight | 417.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H18Cl2N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Fenmetozole TosylateFenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant drug. |
| Name | Fenmetozole Tosylate |
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| Description | Fenmetozole Tosylate is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor, and acts as an antidepressant drug. |
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| Related Catalog | |
| In Vitro | Fenmetozole acts as an antagonist of α2-adrenergic receptor[3]. |
| In Vivo | In mice, fenmetozole antagonizes both the ethanol induced increase in locomotor activity at 2.0 g/kg and the decrease caused by 4.0 g/kg. Moreover, fenmetozole attenuates the ethanol-induced reduction in cerebellar cyclic guanosine monophosphate content, but it significantly elevates cGMP levels in this tissue. Fenmetozole does not change ethanol induced increases in punished drinking in a conflict test, but when given at a high dose, fenmetozole decreases both punished and unpunished responding. Fenmetozole fails to precipitate ethanol withdrawal-like reactions when it is given to physically-dependent, intoxicated rats. Fenmetozole (15-30 g/kg) reduces ethanol-induced impairment of the aerial righting reflex without altering blood or brain ethanol content[1]. Fenmetozole alone has no ffect on punished drinking and does not alter ethanol action in the paradigm except at the highest dose tested (30 mg/kg) in rats[2]. |
| References |
| Molecular Formula | C17H18Cl2N2O4S |
|---|---|
| Molecular Weight | 417.31 |
| Storage condition | 2-8℃ |