Desethylamiodarone

Modify Date: 2025-08-25 19:38:46

Desethylamiodarone structure	Common Name	Desethylamiodarone
	CAS Number	83409-32-9	Molecular Weight	617.25800
	Density	1.638 g/cm3	Boiling Point	630.3ºC at 760 mmHg
	Molecular Formula	C₂₃H₂₅I₂NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	335ºC

Use of Desethylamiodarone

Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis[1][2].

Name	(2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone
Synonym	More Synonyms

Description	Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Bognar Z, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS One. 2017 Dec 8;12(12):e0189470. [2]. Kannan R, et al. Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats. Fundam Appl Toxicol. 1991 Jan;16(1):103-9.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Bognar Z, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS One. 2017 Dec 8;12(12):e0189470.

[2]. Kannan R, et al. Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats. Fundam Appl Toxicol. 1991 Jan;16(1):103-9.

Density	1.638 g/cm3
Boiling Point	630.3ºC at 760 mmHg
Molecular Formula	C₂₃H₂₅I₂NO₃
Molecular Weight	617.25800
Flash Point	335ºC
Exact Mass	616.99200
PSA	51.47000
LogP	6.59480
Index of Refraction	1.635

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4939000

CHEMICAL NAME :: Methanone, (2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5 -diiodophenyl)-

CAS REGISTRY NUMBER :: 83409-32-9

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H25-I2-N-O3

MOLECULAR WEIGHT :: 617.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1380 mg/kg/23D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in phosphorus

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,103,1991

N-Desethylamiodarone

Desethylamiodarone

N-Deethylamiodarone

Methanone,(2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)

N-Monodesethylamiodarone

(2-butyl-1-benzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone

(2-Butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone

Deethylamiodarone

Amiodarone Impurity 2

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