Desethylamiodarone

Names

[ Name ]:
Desethylamiodarone

[Synonym ]:
N-Desethylamiodarone
Desethylamiodarone
N-Deethylamiodarone
Methanone,(2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)
N-Monodesethylamiodarone
(2-butyl-1-benzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone
(2-Butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone
Deethylamiodarone
Amiodarone Impurity 2

Biological Activity

[Description]:

Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Bognar Z, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS One. 2017 Dec 8;12(12):e0189470.

[2]. Kannan R, et al. Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats. Fundam Appl Toxicol. 1991 Jan;16(1):103-9.

Chemical & Physical Properties

[ Density]:
1.638 g/cm3

[ Boiling Point ]:
630.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₅I₂NO₃

[ Molecular Weight ]:
617.25800

[ Flash Point ]:
335ºC

[ Exact Mass ]:
616.99200

[ PSA ]:
51.47000

[ LogP ]:
6.59480

[ Index of Refraction ]:
1.635

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4939000

CHEMICAL NAME :: Methanone, (2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5 -diiodophenyl)-

CAS REGISTRY NUMBER :: 83409-32-9

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H25-I2-N-O3

MOLECULAR WEIGHT :: 617.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1380 mg/kg/23D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in phosphorus

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,103,1991