DCPIB
Modify Date: 2024-01-02 14:24:35
DCPIB structure
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Common Name | DCPIB | ||
|---|---|---|---|---|
| CAS Number | 82749-70-0 | Molecular Weight | 427.36 | |
| Density | 1.263g/cm3 | Boiling Point | 593.835ºC at 760 mmHg | |
| Molecular Formula | C22H28Cl2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 312.94ºC | |
Use of DCPIBDCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively)[1]. DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells[2]. |
| Name | 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively)[1]. DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells[2]. |
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| Related Catalog | |
| Target |
IC50：0.14 μM (TRESK), 0.95 μM (TASK1), 50.72 μM (TASK3)[1], 4.1 μM (ICl,swell, CPAE cells)[2] |
| References |
| Density | 1.263g/cm3 |
|---|---|
| Boiling Point | 593.835ºC at 760 mmHg |
| Molecular Formula | C22H28Cl2O4 |
| Molecular Weight | 427.36 |
| Flash Point | 312.94ºC |
| Exact Mass | 426.13600 |
| PSA | 63.60000 |
| LogP | 6.34260 |
| Index of Refraction | 1.564 |
| Storage condition | 2-8℃ |
| dcpib |
| hms3268c07 |