5(S),15(S)-DIHETE

Modify Date: 2024-01-11 15:58:36

5(S),15(S)-DIHETE Structure
5(S),15(S)-DIHETE structure
Common Name 5(S),15(S)-DIHETE
CAS Number 82200-87-1 Molecular Weight 336.466
Density 1.0±0.1 g/cm3 Boiling Point 537.6±50.0 °C at 760 mmHg
Molecular Formula C20H32O4 Melting Point N/A
MSDS N/A Flash Point 293.0±26.6 °C

 Use of 5(S),15(S)-DIHETE


5(S)15(S)-DiHETE is an “activated” intermediate, inhibits platelet aggregation with an IC50 of 1.3 μM. 5(S)15(S)-DiHETE enhances the rate of either LXA4 or LXB4 biosynthesis[1].

 Names

Name 5(s), 15(s)-dihete
Synonym More Synonyms

 5(S),15(S)-DIHETE Biological Activity

Description 5(S)15(S)-DiHETE is an “activated” intermediate, inhibits platelet aggregation with an IC50 of 1.3 μM. 5(S)15(S)-DiHETE enhances the rate of either LXA4 or LXB4 biosynthesis[1].
Related Catalog
References

[1]. Abigail R Green, et al. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 Dec 4;57(48):6726-6734.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 537.6±50.0 °C at 760 mmHg
Molecular Formula C20H32O4
Molecular Weight 336.466
Flash Point 293.0±26.6 °C
Exact Mass 336.230072
PSA 77.76000
LogP 3.87
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.527

 Synthetic Route

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5(S),15(S)-DIHETE Structure

5(S),15(S)-DIHETE

CAS#:82200-87-1

Literature: Mulugeta, Surafel; Suzuki, Takashi; Hernandez, Noemi Tejera; Griesser, Markus; Boeglin, William E.; Schneider, Claus Journal of Lipid Research, 2010 , vol. 51, # 3 p. 575 - 585

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5(S),15(S)-DIHETE Structure

5(S),15(S)-DIHETE

CAS#:82200-87-1

Literature: Corey, E. J.; Su, Wei-guo; Cleaver, Martin B. Tetrahedron Letters, 1989 , vol. 30, # 32 p. 4181 - 4184

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

5S,15S-DiHETE
(5S,6E,8Z,11Z,13E,15S)-5,15-Dihydroxy-6,8,11,13-icosatetraenoic acid
5(S),15(S)-DIHETE
5,15-dihydroxy-6,8,11,13-eicosatetraenoicacid
6,8,11,13-Eicosatetraenoic acid, 5,15-dihydroxy-, (5S,6E,8Z,11Z,13E,15S)-