Balanophonin
Modify Date: 2025-08-25 17:00:11
Balanophonin structure
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Common Name | Balanophonin | ||
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| CAS Number | 80286-36-8 | Molecular Weight | 356.36900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BalanophoninBalanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis[1]. |
| Name | (E)-3-[(2R,3S)-2,3-dihydro-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-1-benzo[b]furan-5-yl]-2-propenal |
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| Synonym | More Synonyms |
| Description | Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis[1]. |
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| Related Catalog | |
| Target |
COX-2 p38 |
| In Vitro | Balanophonin (1-10 μM; 24 h) 在 BV2 细胞中降低 Lipopolysaccharides (LPS; HY-D1056) 介导的 TLR4 激活和 NO 生成[1]。 Balanophonin (1-10 μM; 6 h) 降低 LPS 诱导的小胶质细胞中 iNOS 和 COX2 蛋白的表达以及 TNF-α 和 IL-1β 的产生[1]。 Balanophonin (1-10 μM; 30 min) 有效抑制 MAPK 激活[1]。 Balanophonin (1-10 μM; 24 h) 通过调节 N2a 细胞中裂解的 caspase-3 和聚 ADP 核糖聚合酶 (PARP) 的裂解，抑制 LPS 激活的小胶质细胞引起的神经元细胞死亡[1]。 Western Blot Analysis[1] Cell Line: LPS-activated BV-2 cells Concentration: 1, 5, and 10 μM Incubation Time: 30 min for MAPKs, 6 h for iNOS and COX2 and 24 h for PGE2, TNF-α and IL-1β Result: Downregulated TLR4. Reduced iNOS and COX2 expression. Significantly reduced the secretion of TNF-α and IL-1β. Decreased the phosphorylation of MAPKs such as pERK, pJNK, and p-p38. Western Blot Analysis[1] Cell Line: Neuroblastoma N2a cells Concentration: 1, 5, and 10 μM Incubation Time: 24 h Result: Slightly increased Bcl-2. Inhibited caspase-3 activation and PARP cleavage. |
| References |
| Molecular Formula | C20H20O6 |
|---|---|
| Molecular Weight | 356.36900 |
| Exact Mass | 356.12600 |
| PSA | 85.22000 |
| LogP | 2.83110 |
| InChIKey | GWCSSLSMGCFIFR-GWKPYITFSA-N |
| SMILES | COc1cc(C2Oc3c(OC)cc(C=CC=O)cc3C2CO)ccc1O |
| balanophonin |
| (E)-3-[(2R,3S)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(4'-hydroxy-3'-methoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal |
| (E)-3-[(2R,3S)-2-(4-Hydroxy-3-methoxy-phenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-benzofuran-5-yl]-propenal |
| (+)-balanoponin |
| (+)-balanophonin |