EN450
Modify Date: 2024-01-06 23:27:07
EN450 structure
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Common Name | EN450 | ||
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| CAS Number | 793719-01-4 | Molecular Weight | 288.75 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H13ClN2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EN450EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1]. |
| Name | EN450 |
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| Description | EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C11H13ClN2O3S |
|---|---|
| Molecular Weight | 288.75 |