793719-01-4
793719-01-4 structure
- Name: EN450
- Chemical Name: EN450
- CAS Number: 793719-01-4
- Molecular Formula: C11H13ClN2O3S
- Molecular Weight: 288.75
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2023-09-26 16:41:03
- Modify Date: 2024-01-06 23:27:07
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EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1].
| Name | EN450 |
|---|
| Description | EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism[1]. |
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| Molecular Formula | C11H13ClN2O3S |
|---|---|
| Molecular Weight | 288.75 |