Bopindolol fumarate

Modify Date: 2024-01-03 13:50:22

Bopindolol fumarate structure	Common Name	Bopindolol fumarate
	CAS Number	79125-22-7	Molecular Weight	496.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₂N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Bopindolol fumarate

Bopindolol ((±)-Bopindolol) fumarate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol fumarate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol fumarate is a prodrug of pindolol and can be used for essential and renovascular hypertension research[1][2].

Name	Bopindolol fumarate

Description	Bopindolol ((±)-Bopindolol) fumarate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol fumarate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol fumarate is a prodrug of pindolol and can be used for essential and renovascular hypertension research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β1 adrenoceptor β2 adrenoceptor β3 adrenoceptor
In Vivo	Bopindolol (intravenous injection; l8, 16 and 32 μg/kg) fumarate causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1]. Bopindolol (intraperitoneal injection; 3.0 mg/kg) fumarate reduces the diastolic blood pressure (DBP) in pithed rats. And pindolol (1.0 mg/kg) produces similar decreases in DBP of about 8 mmHg. it also produces a dose-dependent decrease in heart rate[2].
References	[1]. D W Harron, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs [2]. H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24(2):373-5. [3]. Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18(8):1066-71.

Molecular Formula	C₂₇H₃₂N₂O₇
Molecular Weight	496.55

DC Chemicals Limited
China
Product Name: Bopindolol fumarate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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