Diclofenac diethylammonium salt

Modify Date: 2024-01-02 01:01:03

Diclofenac diethylammonium salt structure	Common Name	Diclofenac diethylammonium salt
	CAS Number	78213-16-8	Molecular Weight	369.285
	Density	N/A	Boiling Point	412ºC at 760 mmHg
	Molecular Formula	C₁₈H₂₂Cl₂N₂O₂	Melting Point	145-148ºC
	MSDS	N/A	Flash Point	203ºC

Use of Diclofenac diethylammonium salt

Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

Name	Diclofenac diethylamine
Synonym	More Synonyms

Description	Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	Human COX-2:1.3 nM (IC50, in CHO cells) Human COX-1:4 nM (IC50, in CHO cells) Ovine COX-2:0.84 μM (IC50) Ovine COX-1:5.1 μM (IC50)
In Vitro	Diclofenac diethylamine is a potent COX inhibitor, with IC50s of 4 nM and 1.3 nM for human COX-1 and COX-2 in the CHO cells, respectively. Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7 ± 3 nM[1]. Diclofenac sodium exihibits inhibition on COX-1 and COX-2 enzyme with IC50s of 5.1 and 0.84 μM, respectively[2].
In Vivo	Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days[1]. Diclofenac (10 mg/kg) shows anti-inflammatory activity in mice[2]. Diclofenac (10 mg/kg) decreases oxidized low-densitylipoprotein (Ox-LDL), but shows no effects on the kinetics parameters of catalase and glutathione peroxidase via intramuscularly injection into rats[3].
Animal Admin	Rats[1] Male Sprague-Dawley rats (150 ± 200 g) are dosed orally with Diclofenac either once (acute dosing) or twice daily for 5 days (chronic dosing). A plasma sample is obtained 1 h after the morning dose on day 4 for measurement of Diclofenac concentration. Immediately after the administration of the last dose on day 5, the rats are injected via a tail vein with 0.5 mL of 51Cr-labelled red blood cells from a donor rat after incubation with sodium 51chromate. The rats are placed individually in metabolism cages with food and water ad libitum. Faeces are collected for a 48 h period and 51Cr faecal excretion is calculated as a % of total injected dose (20 mCi per animal)[1]. Squirrel monkeys[1] Squirrel monkeys (Saimiri sciureus; 0.8 ± 1.4 kg) are dosed orally with Diclofenac twice daily for 1 ± 5 days. One hour after administration of the last dose, 51CrCl3 in sterile saline (1 mL/kg, 4 ± 5 mCi per animal) is injected via a saphenous vein and plasma samples are obtained for measurement of Diclofenac concentration. The monkeys are then housed individually in metabolism cages. Faeces are collected for a 24 h period and 51Cr faecal excretion is calculated as a % of total injected dose[1].
References	[1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [3]. Curcelli EC, et al. Beneficial effects of diclofenac therapy on serum lipids, oxidized low-density lipoprotein and antioxidant defenses in rats. Life Sci. 2008 Apr 9;82(15-16):892-8.

Boiling Point	412ºC at 760 mmHg
Melting Point	145-148ºC
Molecular Formula	C₁₈H₂₂Cl₂N₂O₂
Molecular Weight	369.285
Flash Point	203ºC
Exact Mass	368.105835
PSA	61.36000
LogP	5.44380

HS Code	2942000000

HS Code	2942000000

N-ethylethanaminium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate

Diclofenac diethylamine

n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate

UNII-6TGQ35Z71K

2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine (1:1)

2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine

Diclofenac (diethylamine)

MFCD01862249

Voltarol

{2-[(2,6-Dichlorophenyl)amino]phenyl}acetic acid - N-ethylethanamine (1:1)

Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with N-ethylethanamine (1:1)

2-[2-(2,6-dichloroanilino)phenyl]acetic acid

Diclofenac diethylammonium salt

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diclofenac diethylamine
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Diclofenac diethylamine
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Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Diclofenac diethylamine
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Purity: 99.0%
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Contact: Anson

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