1,2-Dihydrotanshinquinone

Modify Date: 2024-01-04 23:30:49

1,2-Dihydrotanshinquinone structure	Common Name	1,2-Dihydrotanshinquinone
	CAS Number	77769-21-2	Molecular Weight	278.302
	Density	1.3±0.1 g/cm3	Boiling Point	495.6±44.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	244.6±21.1 °C

Use of 1,2-Dihydrotanshinquinone

1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].

Name	1,6-Dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione
Synonym	More Synonyms

Description	1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1) (≥50% inhibition at 100 µg/mL)[1].
References	[1]. Faleschini MT, et, al. Discovery of natural products potentially active against myotonic dystrophy type 1. Planta Med 2015; 81-YRW_03. [2]. Fronza M, et, al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011 Aug 15;19(16):4876-81.

Density	1.3±0.1 g/cm3
Boiling Point	495.6±44.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₄O₃
Molecular Weight	278.302
Flash Point	244.6±21.1 °C
Exact Mass	278.094299
LogP	4.55
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.629