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1,2-Dihydrotanshinquinone

Names

[ CAS No. ]:
77769-21-2

[ Name ]:
1,2-Dihydrotanshinquinone

[Synonym ]:
Phenanthro(1,2-b)furan-10,11-dione, 8,9-dihydro-1,6-dimethyl-
1,6-Dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione
Phenanthro[1,2-b]furan-10,11-dione, 8,9-dihydro-1,6-dimethyl-

Biological Activity

[Description]:

1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1) (≥50% inhibition at 100 µg/mL)[1].

[References]

[1]. Faleschini MT, et, al. Discovery of natural products potentially active against myotonic dystrophy type 1. Planta Med 2015; 81-YRW_03.

[2]. Fronza M, et, al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011 Aug 15;19(16):4876-81.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
495.6±44.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H14O3

[ Molecular Weight ]:
278.302

[ Flash Point ]:
244.6±21.1 °C

[ Exact Mass ]:
278.094299

[ LogP ]:
4.55

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.629

Related Compounds