(Thr28,Nle31)-Cholecystokinin-33 (25-33) (sulfated)

Modify Date: 2024-01-02 18:32:49

(Thr28,Nle31)-Cholecystokinin-33 (25-33) (sulfated) Structure
(Thr28,Nle31)-Cholecystokinin-33 (25-33) (sulfated) structure
Common Name (Thr28,Nle31)-Cholecystokinin-33 (25-33) (sulfated)
CAS Number 77568-41-3 Molecular Weight 1251.32
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C55H74N14O18S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Thr28,Nle31)-Cholecystokinin-33 (25-33) (sulfated)


[Thr28, Nle31]-Cholecystokinin (25-33) is a biological active peptide. (Cholecystokinin (CCK) acts both as a hormone and a neurotransmitter and is found in the GI system and the central nervous system. It is a satiety peptide that inhibits food intake.This Cholecystokinin (CCK) analog retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements (Thr 28 and Nle31 were substituted for Methionine). The predominant conformation contains a gamma-turn centered on Thr4, separated by Gly5 from a helical segment that comprises the C-terminal residues.)

 Names

Name Arg-Asp-Tyr(SO3H)-Thr-Gly-Trp-Nle-Asp-Phe-NH2
Synonym More Synonyms

  Biological Activity

Description [Thr28, Nle31]-Cholecystokinin (25-33) is a biological active peptide. (Cholecystokinin (CCK) acts both as a hormone and a neurotransmitter and is found in the GI system and the central nervous system. It is a satiety peptide that inhibits food intake.This Cholecystokinin (CCK) analog retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements (Thr 28 and Nle31 were substituted for Methionine). The predominant conformation contains a gamma-turn centered on Thr4, separated by Gly5 from a helical segment that comprises the C-terminal residues.)
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 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C55H74N14O18S
Molecular Weight 1251.32
Exact Mass 1250.502563
PSA 546.41000
LogP 0.56
Index of Refraction 1.677

 Synonyms

L-Phenylalaninamide, L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-norleucyl-4-oxo-O-sulfo-L-homoseryl-N-[(2S)-2-[[(2S)-2-amino-5-[(diaminomethylene)amino]-1-oxopentyl]amino]-3-carboxy-1-oxopropyl]-
RD-sY-TGW-Nle-DF-NH2
(Thr28,Nle31)-Cholecystokinin-33 (25-33)(sulfated)
L-Tyrosyl-L-threonylglycyl-L-tryptophyl-L-norleucyl-4-oxo-O-sulfo-L-homoseryl-N-[(2S)-3-carboxy-2-{[N-(diaminomethylene)-L-ornithyl]amino}propanoyl]-L-phenylalaninamide
(THR28,NLE31)-CHOLECYSTOKININ-33 (25-33) (SULFATED)
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