MEGX (hydrochloride)

Modify Date: 2024-01-24 16:41:37

MEGX (hydrochloride) structure	Common Name	MEGX (hydrochloride)
	CAS Number	7729-94-4	Molecular Weight	242.75
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₉ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MEGX (hydrochloride)

Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation[1][2].

Name	N-(2,6-Dimethylphenyl)-N2-ethylglycinamide hydrochloride (1:1)
Synonym	More Synonyms

Description	Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
References	[1]. Huang YS, et al. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol. 1993 Aug;19(1):140-7. [2]. Esen F, et al. Monoethylglycinexylidide (MEGX) as an early predictor of liver dysfunction in severe sepsis. Critical Care, 1997, 1(Suppl 1):P083.

Description

Related Catalog

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

References

[1]. Huang YS, et al. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol. 1993 Aug;19(1):140-7.

[2]. Esen F, et al. Monoethylglycinexylidide (MEGX) as an early predictor of liver dysfunction in severe sepsis. Critical Care, 1997, 1(Suppl 1):P083.

Molecular Formula	C₁₂H₁₉ClN₂O
Molecular Weight	242.75
Exact Mass	242.11900
PSA	44.62000
LogP	3.69380

Ethylamine

CAS#:75-04-7

2-Chloro-N-(2,6...

CAS#:1131-01-7

~74%

MEGX (hydrochloride)

CAS#:7729-94-4

Literature: CORUS PHARMA Patent: WO2005/63777 A1, 2005 ; Location in patent: Page/Page column 44 ;

N-Ethylglycinhydrochlorid

ethyl glycine hydrochloric acid salt

Glycine,N-ethyl-,hydrochloride

N-(2,6-dimethylphenyl)-2-ethylaminoacetamide hydrochloride

N-Aethyl-glycin-(2,6-dimethyl-anilid),Hydrochlorid

N-desethyl-lidocaine

2-(ethylamino)acetic acid hydrochloride

N-ethyl-glycine-(2,6-dimethyl-anilide),hydrochloride

monoethylglycine xylidide hydrochloride

N-ethyl glycine hydrochloride

N-Aethyl-glycin,Hydrochlorid

Lidocaine Impurity 1

MEGX (hydrochloride)

Use of MEGX (hydrochloride)

Names

MEGX (hydrochloride) Biological Activity

Chemical & Physical Properties

Synthetic Route

Synonyms