7729-94-4

7729-94-4 structure

Name: MEGX (hydrochloride)
Chemical Name: N-(2,6-Dimethylphenyl)-N2-ethylglycinamide hydrochloride (1:1)
CAS Number: 7729-94-4
Molecular Formula: C₁₂H₁₉ClN₂O
Molecular Weight: 242.75
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-01-11 07:19:36
Modify Date: 2024-01-24 16:41:37
Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation[1][2].

Name	N-(2,6-Dimethylphenyl)-N2-ethylglycinamide hydrochloride (1:1)
Synonyms	N-Ethylglycinhydrochlorid ethyl glycine hydrochloric acid salt Glycine,N-ethyl-,hydrochloride N-(2,6-dimethylphenyl)-2-ethylaminoacetamide hydrochloride N-Aethyl-glycin-(2,6-dimethyl-anilid),Hydrochlorid N-desethyl-lidocaine 2-(ethylamino)acetic acid hydrochloride N-ethyl-glycine-(2,6-dimethyl-anilide),hydrochloride monoethylglycine xylidide hydrochloride N-ethyl glycine hydrochloride N-Aethyl-glycin,Hydrochlorid Lidocaine Impurity 1

Description	Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
References	[1]. Huang YS, et al. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol. 1993 Aug;19(1):140-7. [2]. Esen F, et al. Monoethylglycinexylidide (MEGX) as an early predictor of liver dysfunction in severe sepsis. Critical Care, 1997, 1(Suppl 1):P083.

75-04-7

1131-01-7

~74%

7729-94-4

Literature: CORUS PHARMA Patent: WO2005/63777 A1, 2005 ; Location in patent: Page/Page column 44 ;