(D-2-Nal6)-LHRH acetate salt
Modify Date: 2025-08-20 11:21:00
(D-2-Nal6)-LHRH acetate salt structure
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Common Name | (D-2-Nal6)-LHRH acetate salt | ||
|---|---|---|---|---|
| CAS Number | 76932-56-4 | Molecular Weight | 1322.471 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C66H83N17O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (D-2-Nal6)-LHRH acetate saltNafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Sequence: {Glp}-His-Trp-Ser-Tyr-{2-Naph-Ala}-Leu-Arg-Pro-Gly-NH2. |
| Name | Nafarelin |
|---|---|
| Synonym | More Synonyms |
| Description | Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Sequence: {Glp}-His-Trp-Ser-Tyr-{2-Naph-Ala}-Leu-Arg-Pro-Gly-NH2. |
|---|---|
| Related Catalog | |
| Target |
GnRH[1]. |
| In Vitro | Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)[1]. Nafarelin is used effectively in in vitro fertilisation programmes. Nafarelin is readily and rapidly absorbed following intranasal delivery, and is protected to some extent from enzymatic degradation GnRH[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C66H83N17O13 |
| Molecular Weight | 1322.471 |
| Exact Mass | 1321.635620 |
| PSA | 472.13000 |
| LogP | 0.89 |
| Index of Refraction | 1.711 |
| Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| (2S)-N-(2-amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-(2-methylpropyl)-8-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name) |
| Nacenyl |
| (2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name) |
| Nafareline |
| UNII:1X0094V6JV |
| Synarel |
| (2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxo-2-pyrrolidinyl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}-2-pyrrolidinecarboxamide |
| 6-(3-(2-Naphthalenyl)-D-alanine)luteinizing Hormone-releasing Factor |
| glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthalenyl)-D-alanyl-L-leucyl-L-arginyl-L-prolyl- |
| Synrelina |
| Nasanyl |
| Nafarelin Acetate |