MCL0129
Modify Date: 2025-08-26 13:51:02
MCL0129 structure
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Common Name | MCL0129 | ||
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| CAS Number | 768357-45-5 | Molecular Weight | 546.775 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H47FN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MCL0129MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models. Depression Discontinued |
| Name | MCL0129 |
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| Description | MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models. Depression Discontinued |
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| References | References 1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26. 2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400. View Related Products by Target Melanocortin Receptor Depression |
| Molecular Formula | C34H47FN4O |
|---|---|
| Molecular Weight | 546.775 |
| InChIKey | SLGLZEJKMBCODK-MGBGTMOVSA-N |
| SMILES | COc1ccc2ccccc2c1CCCCN1CCN(CC(c2ccc(F)cc2)N2CCN(C(C)C)CC2)CC1 |