FOSALVUDINE TIDOXIL
Modify Date: 2025-09-20 23:32:51
FOSALVUDINE TIDOXIL structure
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Common Name | FOSALVUDINE TIDOXIL | ||
|---|---|---|---|---|
| CAS Number | 763903-67-9 | Molecular Weight | 722.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H64FN2O8PS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FOSALVUDINE TIDOXILFosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1]. |
| Name | (2-decoxy-3-dodecylsulfanylpropyl) [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate |
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| Synonym | More Synonyms |
| Description | Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1]. |
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| Related Catalog | |
| Target |
Nucleoside reverse transcriptase[1] |
| In Vivo | Fosalvudine tidoxil (15-100 mg/kg/day; oral; 8 weeks) 对大鼠产生显著的线粒体肝毒性[1]。 Animal Model: Sprague-Dawley rats[1] Dosage: 15, 40, or 100 mg/kg/day Administration: Oral gavage, 8 weeks Result: Induced significant mtDNA depletion. At doses of 15, 40, and 100 mg/kg, the mean hepatic mtDNA values were 62, 64, and 47% of control values, respectively. |
| References |
| Molecular Formula | C35H64FN2O8PS |
|---|---|
| Molecular Weight | 722.93 |
| Exact Mass | 722.41100 |
| PSA | 164.19000 |
| LogP | 8.78420 |
| InChIKey | JHXLLEDIXXOJQD-WELGVCPWSA-N |
| SMILES | CCCCCCCCCCCCSCC(COP(=O)(O)OCC1OC(n2cc(C)c(=O)[nH]c2=O)CC1F)OCCCCCCCCCC |
| Fosalvudine tidoxil |
| Fosalvudine |
| HDP 99.0003 |