FOSALVUDINE TIDOXIL

Names

[ Name ]:
FOSALVUDINE TIDOXIL

[Synonym ]:
Fosalvudine tidoxil
Fosalvudine
HDP 99.0003

Biological Activity

[Description]:

Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

Nucleoside reverse transcriptase[1]

[In Vivo]

Fosalvudine tidoxil (15-100 mg/kg/day; oral; 8 weeks) 对大鼠产生显著的线粒体肝毒性[1]。 Animal Model: Sprague-Dawley rats[1] Dosage: 15, 40, or 100 mg/kg/day Administration: Oral gavage, 8 weeks Result: Induced significant mtDNA depletion. At doses of 15, 40, and 100 mg/kg, the mean hepatic mtDNA values were 62, 64, and 47% of control values, respectively.

[References]

[1]. Venhoff AC, et al. Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug. Antimicrob Agents Chemother. 2009 Jul;53(7):2748-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₆₄FN₂O₈PS

[ Molecular Weight ]:
722.93

[ Exact Mass ]:
722.41100

[ PSA ]:
164.19000

[ LogP ]:
8.78420

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.