KR-62436
Modify Date: 2025-09-18 11:12:52
KR-62436 structure
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Common Name | KR-62436 | ||
|---|---|---|---|---|
| CAS Number | 761414-79-3 | Molecular Weight | 297.315 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 591.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C14H15N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 311.6±32.9 °C | |
Use of KR-62436KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively; completely inhibits DPP-IV-mediated degradation of GLP-1 in vitro at 10 uM, exhibits selectivity against several proteases including proline-specific protease; promotes primary tumor growth and lung metastasis in a 4T1 tumor allograft mouse model, also shows anti-hyperglycemic activity in vivo. |
| Name | KR-60436 FREE BASE |
|---|---|
| Synonym | More Synonyms |
| Description | KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively; completely inhibits DPP-IV-mediated degradation of GLP-1 in vitro at 10 uM, exhibits selectivity against several proteases including proline-specific protease; promotes primary tumor growth and lung metastasis in a 4T1 tumor allograft mouse model, also shows anti-hyperglycemic activity in vivo. |
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| References | References 1. Kim KR, et al. Eur J Pharmacol. 2005 Jul 25;518(1):63-70. 2. Yang F, et al. Cancer Res. 2018 Dec 24. pii: canres.0620.2018. doi: 10.1158/0008-5472.CAN-18-0620. View Related Products by Target Dipeptidyl Peptidase (DPP) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.6±60.0 °C at 760 mmHg |
| Molecular Formula | C14H15N7O |
| Molecular Weight | 297.315 |
| Flash Point | 311.6±32.9 °C |
| Exact Mass | 297.133820 |
| LogP | -1.35 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.671 |
| InChIKey | XNYVGGJJENHRBZ-UHFFFAOYSA-N |
| SMILES | N#Cc1ccc(NCCNCC(=O)N2N=CCC2C#N)nc1 |
| 3-Pyridinecarbonitrile, 6-[[2-[[2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino]ethyl]amino]- |
| 6-[(2-{[2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino}ethyl)amino]pyridine-3-carbonitrile |
| KR-60436 FREE BASE |
| 6-[(2-{[2-(5-Cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino}ethyl)amino]nicotinonitrile |