Quassin

Modify Date: 2025-08-22 18:12:05

Quassin structure	Common Name	Quassin
	CAS Number	76-78-8	Molecular Weight	388.454
	Density	1.2±0.1 g/cm3	Boiling Point	586.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₈O₆	Melting Point	200 - 222ºC
	MSDS	N/A	Flash Point	255.4±30.2 °C

Use of Quassin

Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2].

Name	quassin
Synonym	More Synonyms

Description	Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2].
Related Catalog	Research Areas >> Endocrinology Research Areas >> Infection
Target	IC50: 0.15 μM (P. falciparum)[2]
In Vitro	Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion[3].
In Vivo	Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats[1]. Animal Model: 35 females albino rats (150-170 g)[1] Dosage: 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg Administration: Oral administration; daily; for 60 days Result: There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats.
References	[1]. Raji Y, et al. Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara. Niger J Physiol Sci. 2010 Nov 24;25(2):95-102. [2]. Mishra K, et al. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin. Exp Parasitol. 2010 Apr;124(4):421-7. [3]. Njar VC, et al. Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro. Planta Med. 1995 Apr;61(2):180-2.

Density	1.2±0.1 g/cm3
Boiling Point	586.3±50.0 °C at 760 mmHg
Melting Point	200 - 222ºC
Molecular Formula	C₂₂H₂₈O₆
Molecular Weight	388.454
Flash Point	255.4±30.2 °C
Exact Mass	388.188599
PSA	78.90000
LogP	2.22
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.553
InChIKey	IOSXSVZRTUWBHC-UHFFFAOYSA-N
SMILES	COC1=CC(C)C2CC3OC(=O)CC4C(C)=C(OC)C(=O)C(C2(C)C1=O)C34C
Storage condition	2-8℃

Hazard Codes	Xi

Precursor 0
DownStream 2
CAS#:26121-57-3 Picrasa-2,12-di... CAS#:30315-04-9 Picrasin B acetate

Einecs 200-985-9

Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy-

2,12-Dimethoxypicrasa-2,12-diene-1,11,16-trione

Quassin,mixture of isomers w/Neoquassin and Isoquassin

11,16-trione,2,12-dimethoxy-picrasa-12-diene-1

Picrasa-2,12-diene-1,11,16-trione,2,12-dimethoxy

Nigakilactone D

Quassin

(3aR,6aR,7aS,8S,11aS,11bS,11cS)-2,10-Dimethoxy-3,8,11a,11c-tetramethyl-3a,6a,7,7a,8,11a,11b,11c-octahydrodibenzo[de,g]chromene-1,5,11(4H)-trione

3ab,6ab,7,7aa,8,11a,11ba,11c-Octahydro-2,10-dimethoxy-3,8a,11ab,11cb-tetramethylphenanthro[10,1-bc]pyran-1,5,11(4H)-trione

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Quassin
Price: Check
Purity: 96.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Quassin
Price: ￥4000.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Quassin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Quassin

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.