Laurdan

Modify Date: 2024-01-07 20:07:58

Laurdan Structure
Laurdan structure
Common Name Laurdan
CAS Number 74515-25-6 Molecular Weight 353.54100
Density 0.987g/cm3 Boiling Point 497.4ºC at 760 mmHg
Molecular Formula C24H35NO Melting Point 88ºC(lit.)
MSDS Chinese USA Flash Point 177.4ºC

 Use of Laurdan


Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of Laurdan can be used to identify phospholipid phase.

 Names

Name 1-[6-(dimethylamino)naphthalen-2-yl]dodecan-1-one
Synonym More Synonyms

 Laurdan Biological Activity

Description Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of Laurdan can be used to identify phospholipid phase.
Related Catalog

 Chemical & Physical Properties

Density 0.987g/cm3
Boiling Point 497.4ºC at 760 mmHg
Melting Point 88ºC(lit.)
Molecular Formula C24H35NO
Molecular Weight 353.54100
Flash Point 177.4ºC
Exact Mass 353.27200
PSA 20.31000
LogP 7.00940
Index of Refraction 1.553

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles56

More Articles
Interactions of beta-blockers with model lipid membranes: molecular view of the interaction of acebutolol, oxprenolol, and propranolol with phosphatidylcholine vesicles by time-dependent fluorescence shift and molecular dynamics simulations.

Eur. J. Pharm. Biopharm. 87(3) , 559-69, (2014)

Since pharmacokinetic and pharmacodynamic activities of drugs are often related to their interactions with biomembranes, it is of high interest to establish an approach for the characterization of the...

Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties.

J. Lipid Res. 56 , 2158-71, (2015)

Cytotoxic bile acids, such as deoxycholic acid (DCA), are responsible for hepatocyte cell death during intrahepatic cholestasis. The mechanisms responsible for this effect are unclear, and recent stud...

Molecular mechanism of action of chlorogenic acid on erythrocyte and lipid membranes.

Mol. Membr. Biol. 32 , 46-54, (2015)

The high antioxidant capacity of chlorogenic acid (CGA) in respect to biological systems is commonly known, though the molecular mechanism underlying that activity is not known. The aim of the study w...

 Synonyms

6-Dodecanoyl-N,N-dimethyl-2-naphthylamine
N,N-Dimethyl-6-dodecanoyl-2-naphthylamine
Laurdan
2-(Dimethylamino)-6-dodecanoylnaphthalene
6-Dodecanoyl-2-dimethylaminonaphthalene